Molecular Basis for CA2+ Channel Diversity
نویسندگان
چکیده
منابع مشابه
Molecular diversity of Ca2+ channel beta subunits.
Introduction Voltage-gated Ca2+ channels have been extensively characterized in terms of their pharmacological, electrophysiological, biochemical, and molecular biological properties. Calcium channels are multisubunit complexes composed of an ion-conducting subunit, a ,, and smaller accessory subunits. Molecular cloning studies have concentrated on the a , subunit because it appears to determin...
متن کاملMolecular Basis of Ca2+ Activation of the Mouse Cardiac Ca2+ Release Channel (Ryanodine Receptor)
Activation of the cardiac ryanodine receptor (RyR2) by Ca(2)+ is an essential step in excitation-contraction coupling in heart muscle. However, little is known about the molecular basis of activation of RyR2 by Ca(2)+. In this study, we investigated the role in Ca(2)+ sensing of the conserved glutamate 3987 located in the predicted transmembrane segment M2 of the mouse RyR2. Single point mutati...
متن کاملMolecular basis for catecholaminergic neuron diversity.
Catecholaminergic neurons control diverse cognitive, motor, and endocrine functions and are associated with multiple psychiatric and neurodegenerative disorders. We present global gene-expression profiles that define the four major classes of dopaminergic (DA) and noradrenergic neurons in the brain. Hypothalamic DA neurons and noradrenergic neurons in the locus coeruleus display distinct group-...
متن کاملMolecular basis of the CRAC channel.
Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitting Ca(2+) entry and sustained [Ca(2+)](i) signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade th...
متن کاملMolecular Basis for Antigenic Diversity of Genus Betanodavirus
Betanodaviruses are the causative agents of viral nervous necrosis (VNN), a devastating disease for the Mediterranean mariculture. Four different betanodavirus species are recognized, Striped jack-, Redspotted grouper-, Tiger puffer-, and Barfin flounder nervous necrosis virus (SJNNV, RGNNV, TPNNV and BFNNV), but there is little knowledge on their antigenic properties. In order to describe the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Neuroscience
سال: 1994
ISSN: 0147-006X
DOI: 10.1146/annurev.neuro.17.1.399